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Mechanisms of Ageing and Development 122 (2001) 2107– 2121 www.elsevier.com/locate/mechagedev Contents of volume 122 Volume 122 No. 1 January 2001 ...

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Mechanisms of Ageing and Development 122 (2001) 2107– 2121 www.elsevier.com/locate/mechagedev

Contents of volume 122 Volume 122 No. 1

January 2001

Perspective Glutamatergic neurotransmission in aging: a critical perspective G. Segovia, A. Porras, A. Del Arco, F. Mora (Madrid, Spain) . . . .

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Regular articles Retinoic acid modulates the asialoglycoprotein receptor expression in cultured fetal rat hepatocytes L. Falasca, A. Felici, M. Massimi, L. Dini, L. Conti Devirgiliis (Rome, Italy) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice V.N. Anisimov, V.Kh. Khavinson, A.I. Mikhalski, A.I. Yashin (St. Petersburg, Moscow, Russia; Rostock, Germany). . . . . . . . . . High sensitivity to autoxidation in neonatal calf erythrocytes: possible mechanism of accelerated cell aging S. Imre, M. Csornai, M. Balazs (Debrecen, Hungary) . . . . . . . . . Blood pressure, ventricular volume and number of cardiomyocyte nuclei in rats fed for 12 months on diets differing in fat composition M.B. Aguila, C. Alberto Mandarim-de-Lacerda (Rio de Janeiro, Brazil) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Bone anabolic effects of separate and combined therapy with growth hormone and parathyroid hormone on femoral neck in aged ovariectomized osteopenic rats L. Wang, P.B. Orhii, J. Banu, D.N. Kalu (San Antonio, TX) . . . . . Evidence for an alteration of plasma and liver proteins response to dexamethasone in aging rats I. Savary, E. Debras, D. Dardevet, F. Rambourdin, M.-P. Vasson, C. Obled, J. Grizard (St Gene`s Champanelle, Clermont Ferrand, France) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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Instructions to Authors . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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Volume 122 No. 2

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February 2001

First Editorial Office of Mechanisms of Ageing and Development in Asia S. Chul Park, Y. Suh . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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Editorial Opinion J. Vijg, Ph.D., Editor (San Antonio, TX) . . . . . . . . . . . . . . . . .

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Opinion The SENIEUR Protocol after 16 years: a need for a paradigm shift? S.C. Castle, K. Uyemura, T. Makinodan (Los Angeles, CA) . . . . .

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Response 1 New paradigms for research on aging and late-life illness R.A. Miller (Ann Arbor, MI) . . . . . . . . . . . . . . . . . . . . . . .

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Response 2 The SENIEUR protocol after 16 years G. Pawelec, F.G. Ferguson, A. Wikby (Tu¨ bingen, Germany; University Park, PA; Jo¨ nko¨ ping, Sweden) . . . . . . . . . . . . . . . . . . . . . . .

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Response 3 The value of the SENIEUR protocol: distinction between ‘ideal aging’ and clinical reality W.B. Ershler (Washington, DC) . . . . . . . . . . . . . . . . . . . . . .

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Response 4 The SENIEUR protocol after 16 years: the next step is to study the interaction of ageing and disease G.H. Ligthart (Amsterdam, The Netherlands) . . . . . . . . . . . . . .

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Regular articles Differences in DNA synthesis in vitro using isolated nuclei from regenerating livers of young and aged rats T. Taguchi, M. Fukuda, M. Ohashi (Tokyo, Japan) . . . . . . . . . . Does MMP-2 expression and secretion change with increasing serial passage of keratocytes in culture? S.R. Sandeman, R.G.A. Faragher, M.C.A. Allen, C. Liu, A.W. Lloyd (Brighton, UK) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . On the anti-aging activities of aminoguanidine and N-t-butylhydroxylamine A.R. Hipkiss (London, UK) . . . . . . . . . . . . . . . . . . . . . . . .

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A mouse genetic locus with death clock and life clock features D.D. Adams, W.O. Lucas, B.G. Williams, B.B. Berkeley, K.W. Turner, J.C. Schofield (Dunedin, New Zealand) . . . . . . . . . . . . . . . . . . Regular moderate intensity physical activity and blood concentrations of endogenous anabolic hormones and thyroid hormones in aging men G. Ravaglia, P. Forti, F. Maioli, L. Pratelli, C. Vettori, L. Bastagli, E. Mariani, A. Facchini, D. Cucinotta (Bologna, Italy) . . . . . . . . . . Mitochondrial membrane potential and ageing in Podospora anserina F. Koll, C. Sidoti, V. Rincheval, G. Lecellier (Gif sur Yvette, Versailles, France) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Role of lymphoid cells in age-related change of susceptibility to Friend leukemia virus-induced leukemia S. Yamaguchi, M. Kitagawa, M. Inoue, Y. Tejima, M. Kimura, S. Aizawa, M. Utsuyama, K. Hirokawa (Tokyo, Chiba, Japan) . . . . .

Volume 122 No. 3

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March 2001

Review Caretaker or undertaker? The role of the proteasome in aging M. Gaczynska, P.A. Osmulski, W.F. Ward (San Antonio, TX) . . . . Regular articles Multidrug resistance gene expression during the murine ontogeny M. Schiengold, L. Schwantes, G. Schwartsmann, J.A.B. Chies, N.B. Nardi (Porto Alegre, Brazil) . . . . . . . . . . . . . . . . . . . . . . . . A system approach modelling of the three-stage non-linear kinetics in biological ageing G.U. Crevecoeur (Charleroi, Belgium). . . . . . . . . . . . . . . . . . . Relationship between NADP-specific isocitrate dehydrogenase and glutathione peroxidase in aging rat skeletal muscle J.M. Lawler, S.R. Demaree (College Station, TX) . . . . . . . . . . . . Aged mice exhibit in vivo defective peripheral clonal deletion of Db/H-Y reactive CD8 + T cells H.-C. Hsu, T. Zhou, J. Shi, P.A. Yang, D. Liu, H.-G. Zhang, H. Bluethmann, J.D. Mountz (Birmingham, AL; Basel, Switzerland) . . . Similarities and dissimilarities of newborn and adolescent rats in the binding capacity of thymic glucocorticoid receptors ´ . Inczefi-Gonda (Budapest, Hungary) . . . . . . . . . . . . G. Csaba, A An elevation in the concentration of HLA class I molecules in human blood due to ageing C. Le Morvan, M. Cogne´, M. Drouet (Limoges, France) . . . . . . . Immunological restoration and anti-tumor effect by Japanese herbal medicine in aged mice M. Utsuyama, H. Seidlar, M. Kitagawa, K. Hirokawa (Tokyo, Japan)

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Erratum Erratum to ‘Zinc, infections and immunosenescence’ [Mech. Ageing Develop. 121(2000) 21– 35] . . . . . . . . . . . . . . . . . . . . . . . . .

Volume 122 No. 4

15 April 2001

Regular articles Age-associated changes in gene expression patterns in the duodenum and colon of rats H.-M. Lee, G.H. Greeley Jr, E.W. Englander (Galveston, TX) . . . . Age-dependent IGF-1 regulation of gene transcription of Ca2 + channels in skeletal muscle Z. Zheng, M.L. Messi, O. Delbono (Winston-Salem, NC) . . . . . . . Glucagon and vasopressin V1a receptor signaling in hepatocytes from aging rats L. Teillet, S. Gouraud, L. Preisser, T. Tordjmann, A. Morel, B. Corman (Gif-sur-Yvette, Paris, Orsay, Angers, France) . . . . . . . . . . . . . . Endogenous glutamate– taurine interaction in striatum and nucleus accumbens of the freely moving rat: studies during the normal process of aging A. Del Arco, G. Segovia, L. Prieto, F. Mora (Madrid, Spain) . . . . Age-related changes in oxidative damage to lipids and DNA in rat skin S. Tahara, M. Matsuo, T. Kaneko (Tokyo, Hyogo, Japan) . . . . . . Effect of the degree of fatty acid unsaturation of rat heart mitochondria on their rates of H2O2 production and lipid and protein oxidative damage A. Herrero, M. Portero-Otı´n, M. Josep Bellmunt, R. Pamplona, G. Barja (Madrid, Lleida, Spain) . . . . . . . . . . . . . . . . . . . . .

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Review Immunogenetics of longevity. Is major histocompatibility complex polymorphism relevant to the control of human longevity? A review of literature data C. Caruso, G. Candore, G.C. Romano, D. Lio, M. Bonafe`, S. Valensin, C. Franceschi (Palermo, Bologna, Ancona, Italy) . . . . . . . . . . . . Regular articles Long-live euthymic BALB/c-nu mice. I. Survival study suggests body weight as a life span predictor L. Piantanelli, A. Zaia, G. Rossolini, A. Piantanelli, A. Basso, V.N. Anisimov (Ancona, Italy; St. Petersburg, Russian Federation) . Long-live euthymic BALB/c-nu mice. II: spontaneous tumors and other pathologies

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V.N. Anisimov, M.A. Zabezhinski, G. Rossolini, A. Zaia, A. Piantanelli, A. Basso, L. Piantanelli (St. Petersburg, Russia; Ancona, Italy) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Effects of L-phenylalanine on acetylcholinesterase and Na + , K + -ATPase activities in adult and aged rat brain S. Tsakiris (Athens, Greece) . . . . . . . . . . . . . . . . . . . . . . . .

Volume 122 No. 6

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15 July 2001

Regular articles Aged rat hearts are not more susceptible to ischemia-reperfusion injury in vivo: role of glutathione S. Leichtweis, C. Leeuwenburgh, J. Bejma, L.L. Ji (Madison, WI) . . Endothelin-1 receptors on cultured rat articular chondrocytes: regulation by age, growth factors, and cytokines, and effect on cAMP production H. Messai, A. Panasyuk, A.-M. Khatib, A. Barbara, D.R. Mitrovic (Paris, France; Moscow, Russia) . . . . . . . . . . . . . . . . . . . . . . Aging and glucose transporter plasticity in response to hypobaric hypoxia R.P. Dill, S.G. Chadan, C. Li, W.S. Parkhouse (British Columbia, Canada) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . A new murine oxidative stress model associated with senescence R. Feng, W. He, H. Ochi (Beijing, People’s Republic of China; Haruoka, Japan) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Effects of age and strain on small intestinal and hepatic antioxidant defense enzymes in Wistar and Fisher 344 rats I.S. Jang, K.R. Chae, J.S. Cho (Kyung-Nam, Seoul, South Korea) . .

Volume 122 No. 7

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31 May 2001

Editorial Filling a void in a field that has come of age . . . . . . . . . . . . . . . . Viewpoints Why only time will tell S. Hekimi, C. Be´ nard, R. Branicky, J. Burgess, A.K. Hihi, S. Rea (Montreal, Canada) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Proteolysis, caloric restriction and aging K. Merker, A. Stolzing, T. Grune (Berlin, Germany) . . . . . . . . . . Peroxidation of linoleic acid and its relation to aging and age dependent diseases G. Spiteller (Bayreuth, Germany) . . . . . . . . . . . . . . . . . . . . .

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Emerging roles for telomerase in regulating cell differentiation and survival: a neuroscientist’s perspective M.P. Mattson, W. Fu, P. Zhang (Baltimore, MD) . . . . . . . . . . . Reviews Insulin-like signaling, metabolism, stress resistance and aging in Caenorhabditis elegans B.P. Braeckman, K. Houthoofd, J.R. Vanfleteren (Ghent, Belgium) . Telomere biology in human aging and aging syndromes W. Klapper, R. Parwaresch, G. Krupp (Kiel, Germany) . . . . . . . . Stem cells and aging: expanding the possibilities M.S. Rao, M.P. Mattson (Baltimore, MD; Salt Lake City, UT) . . . Molecular mechanisms of ageing in connective tissues A.J. Bailey (Bristol, UK) . . . . . . . . . . . . . . . . . . . . . . . . . . Suppression of brain aging and neurodegenerative disorders by dietary restriction and environmental enrichment: molecular mechanisms M.P. Mattson, W. Duan, J. Lee, Z. Guo (Baltimore, MD) . . . . . .

Volume 122 No. 8

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June 2001

Regular articles Retinoic acid down-regulates the expression of EmH-3 homeobox-containing gene in the freshwater sponge Ephydatia muelleri E. Nikko, G. Van de Vyver, E. Richelle-Maurer (Gosselies, Belgium) Influence of treatment with Ca2 + antagonists on cerebral vasculature of spontaneously hypertensive rats M. Sabbatini, D. Tomassoni, F. Amenta (Camerino, Italy) . . . . . . Enzyme activities in the light of the membrane hypothesis of aging: [An answer to K. Kitani, Mech. Ageing Dev. 107 (1999) 299–322] I. Zs.-Nagy (Debrecen, Hungary) . . . . . . . . . . . . . . . . . . . . . Decreased Pasteur effect in platelets of aged individuals M. D’Aurelio, M. Merlo Pich, L. Catani, G.L. Sgarbi, C. Bovina, G. Formiggini, G.P. Castelli, H. Baum, S. Tura, G. Lenaz (Bologna, Italy; London, UK) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Total antioxidant levels, gender, and age as risk factors for DNA damage in lymphocytes of the elderly V.M. Mendoza-Nu´ n˜ ez, M.A. Sa´ nchez-Rodrı´guez, R. Retana-Ugalde, L.A. Vargas-Guadarrama, M.A. Altamirano-Lozano (Mexico City, Mexico) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Analysis of the effects of growth hormone, exercise and food restriction on cancellous bone in different bone sites in middle-aged female rats J. Banu, P.B. Orhii, M.C. Okafor, L. Wang, D.N. Kalu (San Antonio, TX). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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15 July 2001

Viewpoints New clues to old yeast S.M. Jazwinski (New Orleans, LA) . . . . . . . . . . . . . . . . . . . . Neuronal regulation of lifespan: clues from flies and worms G.L. Boulianne (Toronto, ON, Canada) . . . . . . . . . . . . . . . . . Sphingomyelin and ceramide as regulators of development and lifespan R.G. Cutler, M.P. Mattson (Baltimore, MD) . . . . . . . . . . . . . . Recent advances in human gene–longevity association studies G. De Benedictis, Q. Tan, B. Jeune, K. Christensen, S.V. Ukraintseva, M. Bonafe`, C. Franceschi, J.W. Vaupel, A.I. Yashin (Rende, Bologna, Italy; Rostock, Germany; Odense, Denmark). . . . . . . . . . . . . . . Reviews Unwinding the molecular basis of the Werner syndrome J.-C. Shen, L.A. Loeb (Seattle, WA) . . . . . . . . . . . . . . . . . . . Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins D.A. Butterfield, J. Kanski (Lexington, KY) . . . . . . . . . . . . . . . Impact of aging on stress-responsive neuroendocrine systems W.A. Pedersen, R. Wan, M.P. Mattson (Baltimore, MD) . . . . . . . Age-related changes of DNA damage recognition and repair capacity in cells of the immune system G. Doria, D. Frasca (Rome, Italy) . . . . . . . . . . . . . . . . . . . .

Volume 122 No. 10

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Review Array-based gene expression profiling to study aging E.-S. Han, S.G. Hilsenbeck (San Antonio, TX; Houston, TX). . . . . Regular articles Age-dependent fatigue in single intact fast- and slow fibers from mouse EDL and soleus skeletal muscles E. Gonza´ lez, O. Delbono (Winston-Salem, NC) . . . . . . . . . . . . . Caloric restriction alters the feeding response of key metabolic enzyme genes J.M. Dhahbi, P.L. Mote, J. Wingo, B.C. Rowley, S.X. Cao, R.L. Walford, S.R. Spindler (Riverside, CA; Los Angeles, CA) . . . . Age related changes of the collagen network of the human heart C.R. Gazoti Debessa, L.B. Mesiano Maifrino, R. Rodrigues de Souza (Sao Paulo, Brazil) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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Effect of 17-b estradiol and epidermal growth factor on DNA and RNA labeling in astroglial cells during development, maturation and differentiation in culture N. Marletta, D. Licciardello, G.F. Cormaci, M. Sabbatini, A. D’Assoro, G. Venardi, V. Spina-Purrello, F. Stivala, B. Marchetti, R. Avola (Catania, Camerino, Camerino, Troina, Sassari, Italy) . . . . . . . . . Increased calcium vulnerability of senescent cardiac mitochondria: protective role for a mitochondrial potassium channel opener A. Jahangir, C. Ozcan, E.L. Holmuhamedov, A. Terzic (Rochester, MN) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Volume 122 No. 11

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August 2001

Progress Tailoring cancer vaccines to the elderly: the importance of suitable mouse models C. Gravekamp (San Antonio, TX) . . . . . . . . . . . . . . . . . . . . . Regular articles The DNA helicase activity of yeast Sgs1p is essential for normal lifespan but not for resistance to topoisomerase inhibitors H.W. Mankouri, A. Morgan (Liverpool, UK) . . . . . . . . . . . . . . Analysis of microsatellite instability and hypermutation of immunoglobulin variable genes in Werner syndrome K. Rosner, D.B. Winter, G.L. Skovgaard, J. Oshima, P.J. Gearhart, V.A. Bohr (Baltimore, MD; Seattle, WA; Copenhagen, Denmark) . . Moderate exercise is associated with enhanced antigen-specific cytokine, but not IgM antibody production in aged mice M.L. Kohut, G.W. Boehm, J.A. Moynihan (Ames, IA; Rochester, NY) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Age-related accumulation of oxidative DNA damage and alterations in levels of p16INK4a/CDKN2a, p21WAF1/CIP1/SDI1 and p27KIP1 in human CD4 + T cell clones in vitro P. Hyland, C. Barnett, G. Pawelec, Y. Barnett (Coleraine, UK; Tuebingen, Germany) . . . . . . . . . . . . . . . . . . . . . . . . . . . . Impaired activation of AP-1 and altered expression of constituent proteins in rat adrenal during ageing R. Medicherla, S. Leers-Sucheta, Y. Luo, S. Azhar (Palo Alto, CA) . Mitochondrial mutations differentially affect aging, mutability and anesthetic sensitivity in Caenorhabditis elegans P.S. Hartman, N. Ishii, E.-B. Kayser, P.G. Morgan, M.M. Sedensky (Fort Worth, TX; Cleveland, OH; Kanagawa, Japan). . . . . . . . . .

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Impaired migration, integrin function, and actin cytoskeletal organization in dermal fibroblasts from a subset of aged human donors M.J. Reed, N.S. Ferara, R.B. Vernon (Seattle, WA) . . . . . . . . . .

Volume 122 No. 12

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September 2001

In Memoriam Dr Bernard L. Strehler . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Review Mutant and genetically modified mice as models for studying the relationship between aging and carcinogenesis V.N. Anisimov (St Petersburg, Russia) . . . . . . . . . . . . . . . . . . Regular articles Microanatomical changes of intracerebral arteries in spontaneously hypertensive rats: a model of cerebrovascular disease of the elderly M. Sabbatini, P. Strocchi, L. Vitaioli, F. Amenta (Camerino, Bologna, Italy) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Cytokine production by stimulated mononuclear cells did not change with aging in apparently healthy, well-nourished women N. Ahluwalia, A.M. Mastro, R. Ball, M.P. Miles, R. Rajendra, G. Handte (University Park, PA) . . . . . . . . . . . . . . . . . . . . . Sequential changes in MR water proton relaxation time detect the process of rat brain myelination during maturation M. Matsumae, D. Kurita, H. Atsumi, M. Haida, O. Sato, R. Tsugane (Kanagawa, Japan). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Acute neutral endopeptidase inhibition is natriuretic in old rats Z. Greenfeld, K. Engels, L. Samsell, C. Baylis (Morgantown, WV) . . Long-term insulin-like growth factor-I expression in skeletal muscles attenuates the enhanced in vitro proliferation ability of the resident satellite cells in transgenic mice M.V. Chakravarthy, M.L. Fiorotto, R.J. Schwartz, F.W. Booth (Houston, TX; Columbia, MO) . . . . . . . . . . . . . . . . . . . . . . . . . . Mutation frequency and type during ageing in mouse seminiferous tubules S.L. Martin, C.L. Hopkins, A. Naumer, M.E.T. Dolle´ , J. Vijg (Denver, CO; San Antonio, TX) . . . . . . . . . . . . . . . . . . . . . . . . . . . Abstracts Stem cells, stress and senescence: Abstracts of presentations at the Annual Scientific Meeting of the BSRA held in London on 14 July 2000 . . .

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15 September 2001

Special Issue Selected papers from the 2nd European Congress on Biogerontology Saint-Petersburg, Russia 25– 28 August, 2000 Guest Editor Vladimir N. Anisimov Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Preface New horizons in biogerontology: from molecules to humans 2nd European Congress on Biogerontology, Saint-Petersburg, Russia, 25 – 28 August 2000 V.N. Anisimov (St. Petersburg, Russia) . . . . . . . . . . . . . . . . . . Replicative mosaicism might explain the seeming contradictions in the telomere theory of aging V.M. Mikhelson (St. Petersburg, Russia) . . . . . . . . . . . . . . . . . Apolipoprotein E alleles in nonagenarian subjects in the Belfast Elderly Longitudinal Free-living Ageing Study (BELFAST) I.M. Rea, I. Mc Dowell, D. McMaster, M. Smye, R. Stout, A. Evans, MONICA group (Belfast) (Belfast, Wales, UK) . . . . . . . . . . . . . An investigation of the age-dependency of chromosome abnormalities in human populations exposed to low-dose ionising radiation I. Vorobtsova, A. Semenov, N. Timofeyeva, A. Kanayeva, I. Zvereva (St. Petersburg, Russia) . . . . . . . . . . . . . . . . . . . . . . . . . . . Different IL-8 production by T and NK lymphocytes in elderly subjects E. Mariani, L. Pulsatelli, A. Meneghetti, P. Dolzani, I. Mazzetti, S. Neri, G. Ravaglia, P. Forti, A. Facchini (Bologna, Italy) . . . . . . Aging impairs intestinal immunity D.L. Schmucker, K. Thoreux, R.L. Owen (San Francisco, CA) . . . . Cyclodextrin modulation of T lymphocyte signal transduction with aging T. Fu¨ lo¨ p Jr., N. Douziech, A.-C. Goulet, S. Desgeorges, A. Linteau, G. Lacombe, G. Dupuis (Que´ bec, Canada). . . . . . . . . . . . . . . . Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups A.R. Hipkiss, C. Brownson, M.J. Carrier (London, UK). . . . . . . . How individual age-associated changes may influence human morbidity and mortality patterns S.V. Ukraintseva, A.I. Yashin (Rostock, Germany; Moscow, Russian Federation; Durham, NC). . . . . . . . . . . . . . . . . . . . . . . . . .

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Use of mathematical models of survivorship in the study of biomarkers of aging: the role of heterogeneity L. Piantanelli, G. Rossolini, A. Basso, A. Piantanelli, M. Malavolta, A. Zaia (Ancona, Italy) . . . . . . . . . . . . . . . . . . . . . . . . . . . Ageing and survival after different doses of heat shock: the results of analysis of data from stress experiments with the nematode worm Caenorhabditis elegans A.I. Yashin, J.R. Cypser, T.E. Johnson, A.I. Michalski, S.I. Boyko, V.N. Novoseltsev (Rostock, Germany; Durham, NC; Boulder, CO; Moscow, Russia) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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Viewpoints Alpha synuclein aggregation: is it the toxic gain of function responsible for neurodegeneration in Parkinson’s disease? S. Rajagopalan, J.K. Andersen (Novato, CA) . . . . . . . . . . . . . . Leptin signaling and aging: insight from caloric restriction I. Shimokawa, Y. Higami (Nagasaki, Japan) . . . . . . . . . . . . . . . Neutrophil ageing and immunesenescence J.M. Lord, S. Butcher, V. Killampali, D. Lascelles, M. Salmon (Birmingham, UK) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Does functional depletion of stem cells drive aging? D. Schlessinger, G. Van Zant (Baltimore, MD; Lexington, KY) . . . Gene therapy and the aging nervous system W.O. Ogle, R.M. Sapolsky (Stanford, CA) . . . . . . . . . . . . . . . . The role of fat cell derived peptides in age-related metabolic alterations I. Gabriely, N. Barzilai (Bronx, NY) . . . . . . . . . . . . . . . . . . . Reviews Mitochondrial DNA mutations, oxidative stress, and aging T.R. Golden, S. Melov (Novato, CA) . . . . . . . . . . . . . . . . . . . The process of aging changes the interplay of the immune, endocrine and nervous systems R.H. Straub, M. Cutolo, B. Zietz, J. Scho¨ lmerich (Regensburg, Germany; Genova, Italy) . . . . . . . . . . . . . . . . . . . . . . . . . . . . Altered T cell signalling in ageing G. Pawelec, K. Hirokawa, T. Fu¨ lo¨ p (Tubingen, Germany; Tokyo, Japan; Sherbrooke, Canada) . . . . . . . . . . . . . . . . . . . . . . . . Transgenic invertebrate models of age-associated neurodegenerative diseases C.D. Link (Boulder, CO) . . . . . . . . . . . . . . . . . . . . . . . . . .

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15 October 2001

Progress The impact energy metabolism and genome maintenance have on longevity and senescence: lessons from yeast to mammals P. Hasty (San Antonio, TX) . . . . . . . . . . . . . . . . . . . . . . . . Regular articles Activated CD8 + T cells from aged mice exhibit decreased activationinduced cell death H.-C. Hsu, J. Shi, P. Yang, X. Xu, C. Dodd, Y. Matsuki, H.-G. Zhang, J.D. Mountz (Birmingham, AL) . . . . . . . . . . . . . . . . . . . . . . Telomere shortening and decline in replicative potential as a function of donor age in human adrenocortical cells L. Yang, T. Suwa, W.E. Wright, J.W. Shay, P.J. Hornsby (Houston, TX; Dallas, TX) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Senescent cells are resistant to death despite low Bcl-2 level M. Sasaki, T. Kumazaki, H. Takano, M. Nishiyama, Y. Mitsui (Hiroshima and Tsukuba, Japan) . . . . . . . . . . . . . . . . . . . . . Dopamine and serotonin uptake inhibitors on the release of dopamine and serotonin in the nucleus accumbens of young and aged rats K. Yoshimoto, B. Kato, S. Ueda, K. Noritake, K. Sakai, M. Shibata, M. Hori, H. Kawano, Y. Takeuchi, Y. Wakabayashi, M. Yasuhara (Kyoto and Tochigi, Japan). . . . . . . . . . . . . . . . . . . . . . . . . Age-related effects of moderate alcohol consumption on GAP-43 levels in rat hippocampus T. Casoli, G. Di Stefano, N. Gracciotti, P. Fattoretti, M. Solazzi, C. Bertoni-Freddari (Ancona, Italy) . . . . . . . . . . . . . . . . . . . . Age-associated changes in cardiac matrix and integrins M.L. Burgess, J.C. McCrea, H.L. Hedrick (Boston, MA; St. Louis, MO; Indianapolis, IN) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Age-related RhoA expression in blood vessels of rats L. Miao, J.W. Calvert, J. Tang, A.D. Parent, J.H. Zhang (Jackson, MS). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Effects of age and food restriction on oxidative DNA damage and antioxidant enzyme activities in the mouse aorta Z.M. Guo, H. Yang, M.L. Hamilton, H. VanRemmen, A. Richardson (San Antonio, TX) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Increase of CD5 + B cells during adolescence in female mice K. Watanabe, M. Watanabe, H. Maruoka, N. Amino, Y. Iwatani (Osaka, Japan) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Age-specific changes in expression, activity, and activation of the c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinases by methyl methanesulfonate in rats Y. Suh (Seoul, South Korea) . . . . . . . . . . . . . . . . . . . . . . . .

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Altered composition and DNA binding activity of the AP-1 transcription factor during the ageing of human fibroblasts A. Sheerin, K.S.J. Thompson, M.H. Goyns (Sunderland and Nottingham, UK) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Effect of morphine on caloric intake and macronutrient selection in male and female Lou/c/jall rats during ageing S. Boghossian, D. Jourdan, M. Dacher, J. Alliot (Aubiere, France) . Succinic dehydrogenase activity in human muscle mitochondria during aging: a quantitative cytochemical investigation P. Fattoretti, J. Vecchiet, G. Felzani, N. Gracciotti, M. Solazzi, U. Caselli, C. Bertoni-Freddari (Ancona and Chieti, Italy). . . . . . . . . Aging is associated with increased proliferation and decreased apoptosis in the colonic mucosa Z.-Q. Xiao, L. Moragoda, R. Jaszewski, J.A. Hatfield, S.E.G. Fligiel, A.P.N. Majumdar (Detroit, MI) . . . . . . . . . . . . . . . . . . . . . . Theory of the age dependence of mortality from congenital defects J. Dolejs (Hradec Kralove, Czech Republic) . . . . . . . . . . . . . . . Automated measurement of age-related changes in the locomotor response to environmental novelty and home-cage activity G. Casadesus, B. Shukitt-Hale, J.A. Joseph (Boston, MA) . . . . . . . Evaluation of phagocytosis and arachidonate metabolism by alveolar macrophages and recruited neutrophils from F344xBN rats of different ages P. Mancuso, R.W. McNish, M. Peters-Golden, T.G. Brock (Ann Arbor, MI). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Short communication Genotyping the Prop-1 mutation in Ames dwarf mice M.E.T. Dolle´ , W.K. Snyder, J. Vijg (San Antonio, TX) . . . . . . . .

Volume 122 No. 16

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Special Issue Alzheimer’s disease versus other degenerative dementia: from biology to treatment Guest Editors V. Gallai F. Amenta L. Parnetti Preface Alzheimer’s disease versus other degenerative dementias: from biology to treatment V. Gallai, F. Amenta, L. Parnetti (Perugia and Camerino, Italy) . . .

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Pathophysiological aspects of frontotemporal dementia— emphasis on cytoskeleton proteins and autoimmunity M. Sjo¨ gren, A. Wallin (Mo¨ lndal, Sweden) . . . . . . . . . . . . . . . . Cerebrospinal fluid cytoskeleton proteins in patients with subcortical whitematter dementia A. Wallin, M. Sjo¨ gren (Mo¨ lndal, Sweden) . . . . . . . . . . . . . . . . Genetic risk factors in familial Alzheimer’s disease S. Sorbi, P. Forleo, A. Tedde, E. Cellini, M. Ciantelli, S. Bagnoli, B. Nacmias (Florence, Italy) . . . . . . . . . . . . . . . . . . . . . . . . Acetylcholinesterase in Alzheimer’s disease V.N. Talesa (Perugia, Italy) . . . . . . . . . . . . . . . . . . . . . . . . . Activation of complement and contact system in Alzheimer’s disease L. Bergamaschini, C. Donarini, G. Gobbo, L. Parnetti, V. Gallai (Milan and Perugia, Italy). . . . . . . . . . . . . . . . . . . . . . . . . . Inflammatory markers in Alzheimer’s disease and multi-infarct dementia A. De Luigi, C. Fragiacomo, U. Lucca, P. Quadri, M. Tettamanti, M. Grazia De Simoni (Milano, Italy; Mendrisio, Switzerland). . . . . Platelet amyloid precursor protein forms in AD: a peripheral diagnostic tool and a pharmacological target A. Padovani, B. Borroni, F. Colciaghi, L. Pastorino, S. Archetti, E. Cottini, L. Caimi, F. Cattabeni, M. Di Luca (Brescia, Italy) . . . . Cerebrospinal fluid t and b-amyloid(1-42) in dementia disorders E. Vanmechelen, H. Vanderstichele, F. Hulstaert, N. Andreasen, L. Minthon, B. Winblad, P. Davidsson, K. Blennow (Ghent, Belgium; Pitea, Malmo, Stockholm, Go¨ teborg and the Medical Research Council, Sweden) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Plasma total homocysteine levels and the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene: a study in an Italian population with dementia T. Bottiglieri, L. Parnetti, E. Arning, T. Ortiz, S. Amici, A. Lanari, V. Gallai (Dallas, TX; Perugia, Italy) . . . . . . . . . . . . . . . . . . . Treatment of cognitive dysfunction associated with Alzheimer’s disease with cholinergic precursors. Ineffective treatments or inappropriate approaches? F. Amenta, L. Parnetti, V. Gallai, A. Wallin (Camerino and Perugia, Italy; Mo¨ lndal, Sweden) . . . . . . . . . . . . . . . . . . . . . . . . . . . Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: an analysis of published clinical data L. Parnetti, F. Amenta, V. Gallai (Perugia and Camerino, Italy) . . . Cerebrospinal fluid acetylcholinesterase activity after long-term treatment with donepezil and rivastigmina S. Amici, A. Lanari, R. Romani, C. Antognelli, V. Gallai, L. Parnetti (Perugia, Italy) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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Pharmacological treatment of non-cognitive disturbances in dementia disorders L. Parnetti, S. Amici, A. Lanari, V. Gallai (Perugia, Italy). . . . . . . Age-related changes of dopamine receptors in the rat hippocampus: a light microscope autoradiography study F. Amenta, F. Mignini, A. Ricci, M. Sabbatini, D. Tomassoni, S.K. Tayebati (Camerino and Roma, Italy). . . . . . . . . . . . . . . . Hypertensive brain damage: comparative evaluation of protective effect of treatment with dihydropyridine derivatives in spontaneously hypertensive rats M. Sabbatini, D. Tomassoni, F. Amenta (Camerino, Italy) . . . . . . Volume contents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Cumulative Author Index of Volume 122 . . . . . . . . . . . . . . . . . . Cumulative Subject Index of Volume 122 . . . . . . . . . . . . . . . . . .

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